Current and Emerging Treatments for Isolated Aortic Stenosis and Concomitant Mitral Stenosis: A Comprehensive Narrative Review.
The Cedars-Sinai NCT07605715 randomized trial of transcatheter vs surgical degenerative MR repair just began recruiting (N=60) — small, but a symbolically important head-to-head in primary MR where surgery currently dominates both guidelines.
The narrative arc: every transcatheter advance carries a downstream reintervention cost when applied to patients with 15+ years of life expectancy.
ACC/AHA's age-65 SAVR threshold and ESC's age-70 SAVR threshold look increasingly defensible against this week's data.
Aortic stenosis (AS) and mitral stenosis (MS) are progressive valvular heart diseases associated with substantial morbidity and mortality once symptoms develop. Over the past decade, the management of isolated AS has undergone profound evolution, driven by refinements in surgical aortic valve replacement, the adoption of minimally invasive techniques, and the rapid expansion of transcatheter aortic valve replacement across all surgical risk categories. In contrast, patients with concomitant AS and MS represent a complex and understudied population, frequently excluded from randomized trials and only marginally addressed in contemporary clinical practice guidelines. The management requires individualized guideline-directed decision-making led by a multidisciplinary Heart Team. The paucity of high-quality data in combined AS-MS underscores the need for dedicated prospective studies and international registries. The aim of this narrative review is to describe current strategies to treat AS both when isolated and concomitant with MS. We also discuss the need for updated, specific guidelines.
- Surgical vs Transcatheter· Medicina (Kaunas, Lithuania)Prognostic Impact of Baseline Albumin-Bilirubin Score on Mortality After Transcatheter Edge-to-Edge Mitral Repair.
- Surgical vs Transcatheter· Medicina (Kaunas, Lithuania)Valve-in-Valve TAVR in Surgical Stentless Aortic Bioprostheses, a Challenging Scenario.
- Surgical vs Transcatheter· Medicina (Kaunas, Lithuania)Categories of Aortic Stenosis: What's New and the Clinical Implications.
- Aortic Valve (TAVR/TAVI)· Giornale italiano di cardiologia (2006)[Ventricular tachycardia and left bundle branch block after transcatheter aortic valve implantation: is the valve guilty forever or not?].
- Aortic Valve (TAVR/TAVI)· American heart journal plus : cardiology research and practiceClinical outcomes following transcatheter aortic valve replacement in patients with concordant versus discordant aortic stenosis.
- Aortic Valve (TAVR/TAVI)· CureusAssociation of Comorbidity Burden With In-Hospital Mortality in Transcatheter Aortic Valve Replacement Patients With Coexisting Malignancy in the United States: A Retrospective Cohort Study.